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DeCS
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Descriptor English:
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Suppressor of Cytokine Signaling 1 Protein
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Descriptor Spanish:
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Proteína 1 Supresora de la Señalización de Citocinas
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Descriptor Portuguese:
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Proteína 1 Supressora da Sinalização de Citocina
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Synonyms English:
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Protein, SOCS1
SOCS1 Protein
Suppressor of Cytokine Signaling Protein 1
Suppressor of Cytokine Signaling Protein 1 -
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Tree Number:
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D12.644.360.024.374.500
D12.776.157.057.249.500
D12.776.476.024.437.500
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Definition English:
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A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56543
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Unique Identifier:
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D000071222
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Occurrence in VHL:
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Similar:
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DeCS
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